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Pregnancy: Safe if travel warrants vaccination.
Injectable typhoid ViCPS (Vi polysaccharide) vaccine is an inactivated subunit vaccine and is considered safe during pregnancy when the risk of typhoid fever warrants vaccination.
Limited formal studies in pregnancy, but extensive post-marketing experience with no safety signals.
Preferred over oral Ty21a (live vaccine) during pregnancy.
WHO recommends vaccination for pregnant travelers to highly endemic areas (South Asia in particular).
Breastfeeding: Safe — no restrictions.
Injectable typhoid ViCPS vaccine is inactivated and poses no risk during breastfeeding. No modification to breastfeeding or vaccination schedule is required.
Pediatric use:
Injectable ViCPS: licensed from 2 years of age.
Children <2 years: ViCPS is not effective due to T-cell-independent polysaccharide response immaturity.
Typhoid conjugate vaccine (TCV, e.g., Typbar-TCV): licensed from 6 months — preferred for young children in endemic settings (WHO prequalified).
Single 0.5 mL IM dose. Revaccinate every 2–3 years if continued exposure.
Geriatric use:
No specific age-related concerns. Standard dose and schedule apply.
Immune response may be slightly reduced in elderly adults, but clinically protective levels are typically achieved.
Food and water precautions remain essential regardless of vaccination status.
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Conditions générales d’utilisationCompare the two typhoid vaccine options for travelers: oral Ty21a (Vivotif) vs injectable Vi polysaccharide. Learn the differences in efficacy, schedule, side effects, cost, and which is better for your trip.