Allurar Rigakafin Haɗin Hanta A+B

Wadanda ya kamata su samu alurar Hepatitis A+B combo:

Matafiya: Duk wanda ke tafiya zuwa yankunan da Hepatitis A da B ke yaduwa — wannan ya hada da kusan duk kasashen Afirka da Asiya.

Ma'aikatan kiwon lafiya: Wadanda ke mu'amala da jini da marasa lafiya — suna bukatar kariya daga Hepatitis B musamman.

Mutane masu yawan tafiya: Sojojin, ma'aikatan agaji, ma'aikatan jirgin ruwa.

Mutane masu cutar hanta ta daban: Masu Hepatitis C, masu cutar hanta na barasa.

Manya da ba su da kariya: Wadanda ba su samu wani alurar Hepatitis A ko B ba.

A Nijeriya:

• Yawancin yara sun riga sun samu alurar Hepatitis B ta hanyar pentavalent a NPI

• Twinrix® na iya zama mai amfani ga manya da ba su samu alurar Hepatitis B a yara ba

• Ana samun ta a wasu asibitocin masu zaman kansu

Ba a ba da alurar Hepatitis A+B combo ga wadannan mutane ba:

Matsanancin rashin lafiyar abubuwan da ke cikin allurar: Musamman rashin lafiyar neomycin, yeast, ko formaldehyde.

Anaphylaxis bayan shan Hepatitis A ko B da ta gabata.

Yara kasa da shekara 1: Ba a amince da Twinrix® ga wannan shekarun ba.

Rashin lafiya mai tsanani tare da zazzabi: Sai a jinkirta.

Ba a hana ba da ita ga:

• Mata masu juna biyu — ana ba da shawarar idan suna cikin hadari

• Masi shayar da nono

• Masu HIV

• Mutane masu raunin garkuwar jiki (amma ingancin na iya raguwa)

Sakamako na alurar Hepatitis A+B combo (Twinrix®):

Sakamako na yau da kullum (30-50%):

• Zafin wurin allura (35-45%)

• Ciwon kai (15-25%)

• Gajiya (10-18%)

• Ciwon tsokoki (8-12%)

• Dan zazzabi (5-8%)

• Tashin zuciya (3-5%)

Wadannan suna warwarewa cikin kwanaki 1-3.

Sakamako masi tsanani: Da wuya sosai — kamar yadda yake ga kowane daga cikin allurar Hepatitis A da B daban-daban.

Bayani: Sakamako na Twinrix® kusan daidai suke da na allurar Hepatitis A da B da aka ba su daban-daban.

Yadda ake ba da alurar Hepatitis A+B combo (Twinrix®):

Jadawali na yau da kullum:

• Allura 3: Watanni 0, 1, da 6

• 1.0 mL ga manya (shekaru 16+)

• IM injection (deltoid)

Jadawalin gaggawa (accelerated):

• Allura 4: Kwanaki 0, 7, 21 + booster a wata 12

• Wannan ya dace ga matafiya da ba su da lokaci

Ajiye alurar: 2-8°C. Kada a daskare.

Samuwar a Nijeriya: Ana samun Twinrix® a wasu asibitocin masi zaman kansu da kantin magunguna a manyan birane. Farashin na iya zama mai tsada ga mutane da yawa.

Ingancin alurar Hepatitis A+B combo:

Bayan cikakken jadawali (allura 3):

• Hepatitis A: 99-100% kariya

• Hepatitis B: 95-99% kariya (anti-HBs ≥10 mIU/mL)

Kwatanta da allurar daban-daban:

• Ingancin Twinrix® kusan daidai yake da yadda za a samu idan an ba da allurar Hepatitis A da B daban-daban

• Fa'idar Twinrix®: Allurar 3 maimakon 5 (2 na Hepatitis A + 3 na Hepatitis B = 5; ko 3 na Twinrix®)

Tsawon kariya:

• Hepatitis A: Shekaru 25-40+ (yiwuwa tsawon rayuwa)

• Hepatitis B: Shekaru 30+ tare da immune memory

Jadawalin gaggawa:

• Kariya ta fi kasa bayan allura 3 na gaggawa — shi ya sa booster na wata 12 yana da muhimmanci

A Nijeriya:

• Twinrix® na iya zama mafi kyawun zabi ga manya da ke bukatar kariya daga duka Hepatitis A da B — yana rage yawan ziyarar asibiti da yawan allura

Mu'amalar alurar Hepatitis A+B combo da wasu magunguna:

Wasu allurar: Ana iya ba da Twinrix® tare da yawancin allurar matafiya (Yellow Fever, Typhoid, Meningococcal, da sauransu) a wurare daban-daban.

Immunoglobulin: Ana iya ba da Hepatitis B Immune Globulin (HBIG) tare da Twinrix® a wurare daban-daban — amma Hepatitis A component na iya samun dan raguwar inganci.

Magunguna masi rage garkuwar jiki: Ingancin na iya raguwa — ana iya bukatar gwajin jini bayan kammala jadawalin.

Bayani: Twinrix® ya fi sauƙi ga matafiya saboda yana rage yawan allurar da ake bukata.

Pregnancy: Twinrix® (inactivated hepatitis A + recombinant hepatitis B) has limited data in pregnancy. Both individual components (hepatitis A and hepatitis B vaccines) have established safety profiles in pregnancy. Hepatitis B vaccination is routinely recommended for pregnant women at risk of HBV infection. Hepatitis A vaccine may be administered during pregnancy when indicated. The theoretical risk from inactivated vaccines during pregnancy is negligible. Consider Twinrix® if both hepatitis A and B protection are needed and the travel timeline is tight.

Breastfeeding: Twinrix® (inactivated) is compatible with breastfeeding. Both hepatitis A and hepatitis B vaccines are inactivated and pose no risk to the breastfed infant. Inactivated vaccines do not replicate and cannot be transmitted through breast milk. No modification of breastfeeding schedule is required. Vaccination of breastfeeding mothers who require hepatitis A and/or B protection should not be deferred.

Pediatric use: Twinrix® is approved for individuals ≥18 years in the United States. A pediatric/adolescent formulation (Twinrix Junior®) is available in some markets for children aged 1–15 years. For children under the approved age, individual hepatitis A and hepatitis B vaccines should be administered separately. Hepatitis A vaccine is recommended from 12 months of age; hepatitis B vaccine is given as part of the routine birth dose series. Children traveling internationally should ideally complete both vaccine series before travel.

Older adults (≥65 years): Twinrix® can be administered to older adults. Immune response to both hepatitis A and hepatitis B components may be diminished in older adults due to immunosenescence. For hepatitis B specifically, seroconversion rates decline with age (approximately 75% in adults ≥60 vs >95% in young adults). Post-vaccination serological testing (anti-HBs) may be considered for older adults at ongoing risk. A higher-dose hepatitis B vaccine (Heplisav-B®) may be used separately if enhanced HBV response is desired.

Matakan kariya:

Idan mutum ya riga ya samu daya daga cikin allurar:

• Idan ya riga ya samu alurar Hepatitis A amma ba Hepatitis B ba (ko akasin haka), za a iya kammala jadawalin ta hanyar ba da allurar da ya rage daban-daban

• Ba a bukatar sake fara jadawalin daga farko ba

Gwajin jini bayan allura:

• Ana ba da shawarar ga ma'aikatan kiwon lafiya don tabbatar da kariya daga Hepatitis B (anti-HBs ≥10 mIU/mL)

A Nijeriya:

• Yawancin manya ba su san ko suna dauke da Hepatitis B ba — ana ba da shawarar gwajin HBsAg kafin fara jadawalin allura

• Idan mutum ya riga ya dauke da Hepatitis B, alurar ba za ta amfane shi ba — yana bukatar magani

• NCDC na ci gaba da wayar da kan jama'a game da gwajin Hepatitis B